Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus

dc.contributor.author	Derese Solomon.
dc.contributor.author	Kerubo Leonidah O.
dc.contributor.author	Midiwo Jacob O.
dc.contributor.author	Langat MK.
dc.contributor.author	Akala HM.
dc.contributor.author	Waters NC.
dc.contributor.author	Peter M.
dc.contributor.author	Heydenreich M.
dc.date.accessioned	2013-06-17T11:51:06Z
dc.date.available	2013-06-17T11:51:06Z
dc.date.issued	2013-02
dc.identifier.citation	Derese, S. 2013. Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus. Natural product communications. 8(2):175-6.	en
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34877
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/23513721
dc.description.abstract	From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 microg/mL respectively.
dc.language.iso	en	en
dc.publisher	University of Nairobi	en
dc.title	Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus	en
dc.type	Article	en
local.publisher	cbps	en