dc.contributor.author | Abosl AO. | |
dc.contributor.author | Mbukwa E. | |
dc.contributor.author | Majinda RR. | |
dc.contributor.author | Raserok BH. | |
dc.contributor.author | Yenesew Abiy. | |
dc.contributor.author | Midiwo Jacob O. | |
dc.contributor.author | Akala H. | |
dc.contributor.author | Liyala P. | |
dc.contributor.author | Waters NC. | |
dc.date.accessioned | 2013-06-18T07:22:20Z | |
dc.date.available | 2013-06-18T07:22:20Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Br J Biomed Sci. 2006;63(3):129-33. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/17058713 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35355 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/17058713 | |
dc.description.abstract | Vangueria infausta burch subsp. infausta (Rubiaceae) produces fruits eaten by humans and animals. The leaf, fruit, stem bark and root bark are used as a remedy for many ailments and the roots are used to treat malaria. In this study, concentrations of fractions of the V. infausta root bark extract that produce 50% inhibition (IC50) are determined using the ability of the extract to inhibit the uptake of [G3H]-hypoxanthine by P. falciparum cultured in vitro. The root bark extract showed antimalarial activity against Plasmodium berghei in mice. It gave a parasite suppression of 73.5% in early infection and a repository effect of 88.7%. One fraction obtained from a chloroform extract gave an IC50 value of 3.8 +/- 1.5 microg/mL and 4.5 +/- 2.3 microg/mL against D6 and W2 strains of P. falciparum, respectively, and another from the butanol extract gave an IC50 value of 3.9 +/- 0.3 microg/mL against the D6 strain. Chloroquine had an IC50 value of 0.016 microg/mL and 0.029 microg/mL against D6 and W2 strains, respectively. The plant showed the presence of flavonoids, coumarins, tannins, terpenoids, anthraquinones and saponins. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Vangueria infausta root bark: in vivo and in vitro antiplasmodial activity | en |
dc.type | Article | en |
local.publisher | Department of Biological Sciences, University of Botswana | en |
local.publisher | College of Biological and Physical Sciences,University of Nairobi | en |