In vitro antiplasmodial and cyclin- dependent protein kinase (pfmrk) inhibitory activities of selected flavonoids in combination with chloroquine (CQ) and artemisinin
Date
2010-08Author
Akala, H M
Waters, CN
Yenesew, A
Wanjala, C
Ayuko Akenga, T
Type
ArticleLanguage
enMetadata
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In this study, we report in vitro chloroquine (CQ) and artemisinin combination studies of eight
flavonoids against Plasmodium falciparum strains. The flavonoids were previously isolated from
Erythrina sp. (Family Leguminosae) growing in Kenya. Synergism was observed for chloroquine/
Sigmoidin E (5) combination at ratios of 5:1 and 3:1 respectively, while other chloroquine/flavonoids
combinations showed variable response; either additive or even antagonistic effects. The
artemisinin/abyssynone IV (1) combination also showed synergistic interaction at a ratio of 5:1. Further
investigations revealed that Abyssinone IV (1) and Abyssinone V (2) were effective inhibitors of
plasmodial growth and differentiation regulatory enzyme, pfmrk.
URI
http://www.academicjournals.org/RPB/PDF/Pdf2010/August/Akala%20et%20al.pdfhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35372
Citation
Research in Pharmaceutical Biotechnology Vol. 2(4), pp. 40-50, August 2010Publisher
University of Nairobi Kenya Medical Research Institute, Walter-Reed Laboratories Department of Chemistry, University of Nairobi Department of Physical Sciences South Eastern University College Office of the Deputy Principal (Academic Affairs), Bondo University College