| dc.contributor.author | Akala, H M | |
| dc.contributor.author | Waters, CN | |
| dc.contributor.author | Yenesew, A | |
| dc.contributor.author | Wanjala, C | |
| dc.contributor.author | Ayuko Akenga, T | |
| dc.date.accessioned | 2013-06-18T07:29:06Z | |
| dc.date.available | 2013-06-18T07:29:06Z | |
| dc.date.issued | 2010-08 | |
| dc.identifier.citation | Research in Pharmaceutical Biotechnology Vol. 2(4), pp. 40-50, August 2010 | en |
| dc.identifier.uri | http://www.academicjournals.org/RPB/PDF/Pdf2010/August/Akala%20et%20al.pdf | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35372 | |
| dc.description.abstract | In this study, we report in vitro chloroquine (CQ) and artemisinin combination studies of eight
flavonoids against Plasmodium falciparum strains. The flavonoids were previously isolated from
Erythrina sp. (Family Leguminosae) growing in Kenya. Synergism was observed for chloroquine/
Sigmoidin E (5) combination at ratios of 5:1 and 3:1 respectively, while other chloroquine/flavonoids
combinations showed variable response; either additive or even antagonistic effects. The
artemisinin/abyssynone IV (1) combination also showed synergistic interaction at a ratio of 5:1. Further
investigations revealed that Abyssinone IV (1) and Abyssinone V (2) were effective inhibitors of
plasmodial growth and differentiation regulatory enzyme, pfmrk. | en |
| dc.language.iso | en | en |
| dc.publisher | University of Nairobi | en |
| dc.subject | Combination studies, CQ, artemisinin, flavonoids, sigmoid E, synergism, antagonism, pfmrk. | en |
| dc.title | In vitro antiplasmodial and cyclin- dependent protein kinase (pfmrk) inhibitory activities of selected flavonoids in combination with chloroquine (CQ) and artemisinin | en |
| dc.type | Article | en |
| local.publisher | Kenya Medical Research Institute, Walter-Reed Laboratories | en |
| local.publisher | Department of Chemistry, University of Nairobi | en |
| local.publisher | Department of Physical Sciences South Eastern University College | en |
| local.publisher | Office of the Deputy Principal (Academic Affairs), Bondo University College | en |
