Correlation of CD4 counts and CD4/CD8 ratio with HIV-infection associated oral manifestations
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Date
2007-08Author
Butt, FM
Vaghela, VP
Chindia, ML
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
BACKGROUND:
The relationship between oral lesions arising from HIV infection and CD4/CD8 cell ratios is of relevance in clinical assessment of immune suppression.
OBJECTIVE:
To correlate the prevalence of oral manifestations arising from HIV infection and the levels of CD4/CD8 cell ratios.
DESIGN:
A cross-sectional study.
SETTING:
Kenyatta National Hospital, Nairobi, Kenya.
SUBJECTS:
Two hundred and seven HIV-infected patients in medical wards were recruited in the study.
RESULTS:
Seventy eight (37.7%) were male and 129 (62.3%) female, with an age range of 18-73 years (mean=34.81 years). Oral manifestations encountered with highest prevalence in the oral cavity included: hyperplastic candidosis (labial mucosa) 15%, erythematous candidosis (gingival) 5%, angular cheilitis 32.4%, herpes simplex (corner of the mouth) 0.5%, persistent oral ulceration (labial mucosa) 0.5%, Parotid enlargement 2% and Kaposis sarcoma (hard/soft palate) 2.9%.
CONCLUSION:
The prevalence of oral manifestations was higher with low CD4 count <200 cell/mm3 and mean CD4/CD8<0.39(95%CI 0.32-0.48)
URI
http://www.ncbi.nlm.nih.gov/pubmed/17970007http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/39372
Citation
East Afr Med J. 2007 Aug;84(8):383-8.Publisher
University of Nairobi Department of Oral and Maxillofacial Surgery, College of Health Sciences, University of Nairobi.
Collections
- Faculty of Health Sciences (FHS) [10378]