| dc.contributor.author | Mitema, ES | |
| dc.date.accessioned | 2013-06-25T13:05:48Z | |
| dc.date.available | 2013-06-25T13:05:48Z | |
| dc.date.issued | 1985-07 | |
| dc.identifier.citation | Arch Int Pharmacodyn Ther. 1985 Jul;276(1):12-6. | en |
| dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/4051633 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/39778 | |
| dc.description.abstract | Quinuronium was shown to have a babesicidal activity in vitro. In vitro/in vivo system with Babesia rodhaini gave an in vitro EC50 for 13.5 ng/ml. Quinuronium levels in ovine plasma increased to a maximum mean of approximately 27 ng/ml at 2 hours with a gradual decay from 8 hours up to almost no detectable levels at 48 hours following administration of therapeutic dose (1 mg/kg s.c.). This study supports previous reports of the use of Babesia rodhaini as an organism in screening antibabesials. The in vitro/in vivo model can be used to monitor quinuronium levels in ovine plasma. Second treatment with quinuronium may be administered after 24 to 48 hours whenever clinically indicated. | en |
| dc.language.iso | en | en |
| dc.publisher | University of Nairobi. | en |
| dc.title | Quinuronium levels in ovine plasma as determined by an in vitro/in vivo system with Babesia rodhaini. | en |
| dc.type | Article | en |
| local.publisher | Department of Public Health, Pharmacology and Toxicology | en |
