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The Discovery of GS-9669, a Thumb Site II Non-nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection
(University of Nairobi, 2013-11-06)
Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure-activity relationships for intrinsic cellular potency. The pharmacokinetic ...
HIV-neutralizing Activity Of Cationic Polypeptides In Cervicovaginal Secretions Of Women In Hiv-serodiscordant Relationships.
(University of Nairobi, 2012)
BACKGROUND:
HIV exposed seronegative (HESN) women represent the population most in need of a prophylactic antiviral strategy. Mucosal cationic polypeptides can potentially be regulated for this purpose and we here aimed ...
Patterns of knee, hip and hand osteoarthritis in Kenyatta National Hospital
(University of Nairobi, 2015)
Background: Osteoarthritis (OA) is one of the most common chronic rheumatic disorders and is associated
with significant morbidity and disability. Few studies examined the spectrum of rheumatic diseases in subSaharan
Africa. ...
Length of coronary sinus in a black Kenyan population: Correlation with heart length
(2015)
Length of coronary sinus is important in the design of cannulation devices used in cardiac
resynchronization therapy and percutaneous mitral valve annuloplasty. It displays gender and
population variations that may account ...
Neurological syndrome in an HIV-prevention trial participant randomized to daily tenofovir disoproxil fumarate (300 mg) and emtricitabine (200 mg) in Bondo, Kenya
(University of Nairobi, 2013-11)
Side effects of antiretroviral drug use by HIV-positive patients have been extensively studied; however, there are limited data on the side effects of antiretroviral drugs used as an HIV prophylaxis among healthy, HIV-negative ...
HIV Prevalence and Risk Behaviors Among Female Sex Workers in Botswana: Results from the 2012 HIV/STI Bio-Behavioral Study
(2014)
To evaluate HIV/STI prevalence among female sex workers (FSWs) in Botswana, and assess
HIV-related risk behaviors. Cross-sectional study using time-location sampling in three districts
of Botswana. Adjusted HIV prevalence ...
Endothelial Dysfunction Is Related to Monocyte Activation in Antiretroviral-Treated People With HIV and HIV-Negative Adults in Kenya
(University of Nairobi, 2020)
Background: Residual monocyte activation may contribute to increased risk for endothelial dysfunction and subsequent atherosclerotic cardiovascular diseases (CVDs) among people with HIV (PWH) on antiretroviral therapy ...
Increased Cervical CD4 + CCR5 + T Cells Among Kenyan Sex Working Women Using Depot Medroxyprogesterone Acetate
(University of Nairobi, 2019)
Depot medroxyprogesterone acetate (DMPA) is the most common hormonal contraceptive used by women in sub-
Saharan Africa, however, it has been epidemiologically associated with HIV infections. To assess whether DMPA
has ...
Factors that affect vaccines availability in public health facilities in Nairobi City County: a cross-sectional study.
(University of Nairobi, 2021)
Introduction
over 1.5 million children die from vaccine-preventable diseases yearly. To avert these deaths and improve their livelihood, vaccine availability is important. The study assessed the availability of the vaccine, ...
Uptake And Correlates Of Contraception Among Postpartum Women In Kenya: Results From A National Cross-Sectional Survey
(University of Nairobi, 2018)
Objective: The objective was to characterize uptake and correlates of effective contraceptive use postpartum.
Study design: We analyzed data from a national, cross-sectional evaluation of prevention of mother-to-child ...