The Genetic Portrait Of An Outbreak Strain

dc.contributor.author	Yesilkaya, H
dc.contributor.author	Forbes, KJ S
dc.contributor.author	hafi, J
dc.contributor.author	Smith, R
dc.contributor.author	Dale, JW
dc.contributor.author	Rajakumar, K
dc.contributor.author	Barer, MR
dc.contributor.author	Andrew, PW
dc.date.accessioned	2013-07-03T07:32:58Z
dc.date.available	2013-07-03T07:32:58Z
dc.date.issued	2006-09
dc.identifier.citation	Tuberculosis (Edinb). 2006 Sep;86(5):357-62. Epub 2005 Dec 19.	en
dc.identifier.uri	http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/16360339
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44465
dc.description.abstract	Unique events in the genome of Mycobacterium tuberculosis, including deletions and IS6110 insertions, have been proposed to be responsible for the virulence phenotype of outbreak strains. Based on this premise, we determined ten IS6110 insertion sites in the genome of the M. tuberculosis CH strain, which was responsible for a large outbreak in Leicestershire, England. Together with previous data on genomic deletions, it was found that 16 genes were mutated either by IS6110 insertions or deletions. The likely impact of these genomic events on the phenotype of the CH strain is discussed.	en
dc.language.iso	en	en
dc.publisher	University of Nairobi	en
dc.title	The Genetic Portrait Of An Outbreak Strain	en
dc.type	Article	en
local.publisher	Institute of Tropica and Infectious Diseases(UNITID)	en