dc.contributor.author | Tanaka, y | |
dc.contributor.author | Hasegawa, I | |
dc.contributor.author | Kato, T | |
dc.contributor.author | Orito, E | |
dc.contributor.author | Hirashima, N | |
dc.contributor.author | Acharya, KS | |
dc.contributor.author | Gish, RG | |
dc.contributor.author | Kramvis, A | |
dc.contributor.author | Kew, MC | |
dc.contributor.author | Yoshihara, N | |
dc.contributor.author | Shrestha, SM | |
dc.contributor.author | Khan, M | |
dc.contributor.author | Miyakawa, Y | |
dc.contributor.author | Mizokami, M | |
dc.date.accessioned | 2013-07-03T14:46:46Z | |
dc.date.available | 2013-07-03T14:46:46Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | KIRTDA, DRACHARYAS. 2004. Tanaka Y, Hasegawa I, Kato T, Orito E, Hirashima N, Acharya SK, Gish RG, Kramvis A, Kew MC, Yoshihara N, Shrestha SM, Khan M, Miyakawa Y, Mizokami M.A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae. Hepatology. 2004 Sep;40(3):747-55.. | en |
dc.identifier.uri | http://profiles.uonbi.ac.ke/sacharya/publications/tanaka-y-hasegawa-i-kato-t-orito-e-hirashima-n-acharya-sk-gish-rg-kramvis-kew- | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44851 | |
dc.description.abstract | There are two subtypes of hepatitis B virus genotype A (HBV/A) and they are provisionally designated Aa ("a" standing for Africa/Asia) and Ae ("e" for Europe). In a case-control study, 78 HBV/Aa, 78HBV/Ae, and 78HBV/D carriers from several countries were compared. The prevalence of HBe antigen (HBeAg) in serum was significantly lower in carriers of HBV/Aa than in carriers of HBV/Ae (31% vs. 49%; P = .033), with a difference more obvious in the carriers aged 30 years or younger (34% vs. 67%; P = .029). HBV DNA levels in the carriers of HBV/Aa (median, 3.46 log copies/mL; 95% CI, 2.93-3.95) were significantly lower than those of carriers of HBV/Ae (6.09 log copies/mL; 95% CI, 4.24-7.64) or of carriers of HBV/D (5.48 log copies/mL; 95% CI, 4.06-7.02), regardless of the HBeAg status (P < .001). The most specific and frequent substitutions in 54 HBV/Aa isolates were double substitutions for T1809 (100%) and T1812 (96%) immediately upstream of the precore initiation codon, which would interfere with the translation of HBeAg in HBV/Aa infections. They were not detected in 57 HBV/Ae or 61 HBV/D isolates examined. The double mutation in the core promoter (T1762/A1764) was more frequent in both HBV/Aa (50%) and HBV/Ae (44%) than in HBV/D isolates (25%; P < .01), whereas the precore mutation (A1896) occurred in HBV/D isolates only (48%; P < .0001). In conclusion, the clearance of HBeAg from serum may occur by different mechanisms in HBV/Aa, HBV/Ae, and HBV/D infections, which may influence clinical manifestations in the Western countries where both genotypes A and D are prevalent. Copyright 2004 American Association for the Study of Liver Diseases | en |
dc.language.iso | en | en |
dc.title | A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae | en |
dc.type | Article | en |
local.publisher | Department of Medicine, College of Health Sciences, University of Nairobi | en |