dc.contributor.author | Acharya, KS | |
dc.date.accessioned | 2013-07-04T09:19:55Z | |
dc.date.available | 2013-07-04T09:19:55Z | |
dc.date.issued | 1997 | |
dc.identifier.citation | KIRTDA, DRACHARYAS. 1997. Magnitude of hepatitis C virus infection in India: prevalence in healthy blood donors, acute and chronic liver diseases. J Med Virol. 1997 Mar;51(3):167-74. | en |
dc.identifier.uri | http://profiles.uonbi.ac.ke/sacharya/publications/magnitude-hepatitis-c-virus-infection-india-prevalence-healthy-blood-donors-ac | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/45192 | |
dc.description.abstract | An enzyme immunoassay (EIA) was developed in-house for the detection of anti-hepatitis C virus (HCV) antibody against the prevailing genotypes in India. The specific reactivity of the test was compared with commercial second and third-generation EIAs and reverse transcription nested polymerase chain reaction (RT-nested PCR). Fifteen thousand nine hundred twenty-two healthy blood donors at the All India Institute of Medical Sciences (AIIMS), New Delhi, India, were screened for anti-HCV antibody. Two hundred ninety-five (1.85%) of these donors were positive. The screening was also used to determine how many patients with acute hepatitis and chronic liver diseases were positive for anti-HCV antibody. Five hundred sixty-four chronic liver disease patients were screened for anti-HCV antibody and 78 (13.83%) were found positive. Two hundred forty-seven sporadic acute viral hepatitis patients were screened for viral infection markers. Hepatitis B and E viruses (HBV and HEV) were the major etiologic agents. HCV was associated with 9% of the acute cases. Anti-HCV core IgM with HCV RNA detection were found to be helpful for the diagnosis of acute HCV infection | en |
dc.language.iso | en | en |
dc.title | Magnitude of hepatitis C virus infection in India: prevalence in healthy blood donors, acute and chronic liver diseases | en |
dc.type | Article | en |