Significance of anti-pre-S antibodies in patients with fulminant hepatic failure
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Date
1990Author
Irshad, M
Gandhi, BM
Acharya, KS
Joshi, YK
Tandon, BN
Type
ArticleLanguage
enMetadata
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Anti-pre-S antibody was tested in 38 sera from patients with fulminant hepatitis (positive for HBsAg and/or IgM anti-HBc) using a specific solid phase enzyme linked immunosorbent assay (ELISA). Anti-pre-S activity was detected in 50 percent sera samples positive for HBsAg but negative for IgM anti-HBc. There were 12.5% sera positive for both HBsAg as well as IgM anti-HBc and 75% sera negative for HBsAg but positive for IgM anti-HBc. The prevalence of HBV-specific DNA-polymerase activity was high in all the three groups whereas anti-HBs positivity was low. Anti-pre-S activity was observed both in the presence as well as in the absence of DNA-polymerase activity. High-anti-pre-S level in fulminant hepatitis B patients was assumed to be implicated in the fast clearance of HBsAg from circulation.
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http://profiles.uonbi.ac.ke/sacharya/publications/irshad-m-gandhi-bm-acharya-sk-joshi-yk-tandon-bnsignificance-anti-pre-s-antibohttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/45642
Citation
KIRTDA, DRACHARYAS. 1990. Irshad M, Gandhi BM, Acharya SK, Joshi YK, Tandon BN.Significance of anti-pre-S antibodies in patients with fulminant hepatic failure.Gastroenterol Jpn. 1990 Aug;25(4):499-502..Publisher
Department of Medicine, College of Health Sciences, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]