Effect of breastfeeding on mortality among HIV-1 infected women: a randomised trial
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Date
2001Author
Nduati, R.
Richardson, B.A.
John, G.
Mbori-Ngacha, D.
Mwatha, A.
Ndinya-Achola, J.
Bwayo, J
Onyango, FE
Kreiss, J
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ArticleLanguage
enMetadata
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Background:
We have completed a randomised clinical trial of breastfeeding and formula feeding to identify the frequency of breastmilk transmission of HIV-1 to infants. However, we also analysed data from this trial to examine the effect of breastfeeding on maternal death rates during 2 years after delivery. We report our findings from this secondary analysis.Methods:Pregnant women attending four Nairobi city council clinics were offered HIVtests. At about 32 weeks' gestation, 425 HIV-1 seropositive women were randomly allocated to either breastfeed or formula feed their infants. After delivery, mother-infant pairs were followed up monthly during the first year and quarterly during the second year until death, or 2 years after delivery, or end of study.
Findings:Mortality among mothers was higher in the breastfeeding group than in the formula group (18 vs 6 deaths, log rank test, p=0.009). The cumulative probability of maternal death at 24 months after delivery was 10.5% in the breastfeeding group and 3.8% in the formula group (p=0.02). The relative risk of death for breastfeeding mothers versus formula feeding mothers was 3.2 (95% CI 1.3-8.1, p=0.01). The attributable risk of maternal death due to breastfeeding was 69%. There was an association between maternal death and subsequent infant death, even after infant HIV-1 infection status was controlled for (relative risk 7.9, 95% CI 3.3-18.6, p<0.001).
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47150http://www.ncbi.nlm.nih.gov/pubmed/11425369
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372408/
Citation
MBORI-, PROFNGACHADOROTHYA. 2001. Effect of breastfeeding on mortality among HIV-1 infected women: a randomised trial. Lancet . 2001 May 26; 357 ( 9269 ): 1651-5 . PMID: 11425369 [PubMed - indexed for MEDLINE] Nduati R, Richardson BA, John G, Mbori-Ngacha D, Mwatha A, Ndinya-Achola J, Bwa. Lancet . 2001 May 26; 357 ( 9269 ): 1651-5 .. : Earthscan, London. 978-1-84407-469-3Publisher
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