Evaluation of dihydropyrimidine dehydrogenase activity in South-west Asian, Kenyan and Ghanaian populations
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Date
2000-09Author
McLeod, Howard L
Ofori-Adjei, David
Indalo Anne.
Githang'a Jessie N.
Ameyaw Margaret-Mary.
Sludden Julieann.
Morsman Janine M.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
AIMS:
Dihydropyrimidine dehydrogenase (DPD) reduces endogenous pyrimidines and therapeutic analogues such as the anticancer agent 5-fluorouracil (5FU). Among Caucasian populations DPD activity is highly variable and subject to polymorphic regulation. To evaluate interethnic influence, DPD activity was assessed in South-west Asian, Kenyan and Ghanaian populations.
METHODS:
DPD activity was determined in peripheral mononuclear cells using[14C]-5-fluorouracil and h.p.l.c. analysis.
RESULTS:
A high degree of variation in DPD activity was observed within each population (range CV = 34-48%). Median DPD activity also varied between these populations. South-west Asian and Kenyan subjects exhibited almost identical median values (192 and 193.5 pmol min(-1) mg(-1), respectively), which were similar to Caucasians (median 215 pmol min(-1) mg(-1). A significantly lower median DPD activity (119 pmol min(-1) mg(-1)) was observed in the Ghanaian population.
CONCLUSIONS:
The similarity in DPD activity between Caucasian, Kenyan and South-west Asian populations suggests that the incidence of 5FU-related toxicity may be comparable in these groups. The pharmacokinetic implications of lower activity amongst Ghanaians needs to be evaluated.
URI
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2000.00242.x/fullhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47160
http://www.ncbi.nlm.nih.gov/pubmed/10971312
Citation
Morsman, J. M., Sludden, J., Ameyaw,, M.-M., Githang'a, J., Indalo, A., Ofori-Adjei, D. and McLeod, H. L. (2000), Evaluation of dihydropyrimidine dehydrogenase activity in South-west Asian, Kenyan and Ghanaian populations. British Journal of Clinical Pharmacology, 50: 269–272.Publisher
Department of Clinical Medicine and Therapeutics
Collections
- Faculty of Health Sciences (FHS) [10378]