dc.contributor.author | McLeod, Howard L | |
dc.contributor.author | Ofori-Adjei, David | |
dc.contributor.author | Indalo Anne. | |
dc.contributor.author | Githang'a Jessie N. | |
dc.contributor.author | Ameyaw Margaret-Mary. | |
dc.contributor.author | Sludden Julieann. | |
dc.contributor.author | Morsman Janine M. | |
dc.date.accessioned | 2013-07-10T14:19:57Z | |
dc.date.available | 2013-07-10T14:19:57Z | |
dc.date.issued | 2000-09 | |
dc.identifier.citation | Morsman, J. M., Sludden, J., Ameyaw,, M.-M., Githang'a, J., Indalo, A., Ofori-Adjei, D. and McLeod, H. L. (2000), Evaluation of dihydropyrimidine dehydrogenase activity in South-west Asian, Kenyan and Ghanaian populations. British Journal of Clinical Pharmacology, 50: 269–272. | en |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2000.00242.x/full | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47160 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/10971312 | |
dc.description.abstract | AIMS:
Dihydropyrimidine dehydrogenase (DPD) reduces endogenous pyrimidines and therapeutic analogues such as the anticancer agent 5-fluorouracil (5FU). Among Caucasian populations DPD activity is highly variable and subject to polymorphic regulation. To evaluate interethnic influence, DPD activity was assessed in South-west Asian, Kenyan and Ghanaian populations.
METHODS:
DPD activity was determined in peripheral mononuclear cells using[14C]-5-fluorouracil and h.p.l.c. analysis.
RESULTS:
A high degree of variation in DPD activity was observed within each population (range CV = 34-48%). Median DPD activity also varied between these populations. South-west Asian and Kenyan subjects exhibited almost identical median values (192 and 193.5 pmol min(-1) mg(-1), respectively), which were similar to Caucasians (median 215 pmol min(-1) mg(-1). A significantly lower median DPD activity (119 pmol min(-1) mg(-1)) was observed in the Ghanaian population.
CONCLUSIONS:
The similarity in DPD activity between Caucasian, Kenyan and South-west Asian populations suggests that the incidence of 5FU-related toxicity may be comparable in these groups. The pharmacokinetic implications of lower activity amongst Ghanaians needs to be evaluated. | en |
dc.language.iso | en | en |
dc.subject | ethnic variability | en |
dc.subject | drug metabolism | en |
dc.subject | dihydropyrimidine dehydrogenase | en |
dc.subject | 5-fluorouracil | en |
dc.title | Evaluation of dihydropyrimidine dehydrogenase activity in South-west Asian, Kenyan and Ghanaian populations | en |
dc.type | Article | en |
local.publisher | Department of Clinical Medicine and Therapeutics | en |