Premedication with temazepam in minor surgery
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Date
1989-10Author
Ratcliff, A
Indalo, A A
Bradshaw, E G
Rye, R M
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Fourteen patients received oral premedication of temazepam in soft gelatin capsules before minor surgery. The plasma concentrations of temazepam and its sedative, anxiolytic and amnesic effects were measured for 24 hours. Absorption was rapid and peak concentrations occurred 49 minutes after administration. Clinical effects were evident at 30 minutes and persisted for about 4 hours. The decline in plasma concentration was biexponential with a distribution half-life of 1.24 hours. The end of the distribution phase coincided approximately with the termination of its clinical effects. A relationship between plasma concentration and effect was observed: concentrations above 300 ng/ml produced measurable changes in tests of mental function. Patients had recovered fully from the effects of temazepam after 24 hours. This dose of temazepam is reliable and efective as premedication before surgery.
URI
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.1989.tb09097.x/abstracthttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47438
Citation
Ratcliff, A., Indalo, A. A., Bradshaw, E. G. And Rye, R. M. (1989), Premedication With Temazepam In Minor Surgery. Anaesthesia, 44: 812–815. Doi: 10.1111/j.1365-2044.1989.tb09097.xPublisher
University of Nairobi College of Health Science
Subject
Premedication; temazepamCollections
- Faculty of Health Sciences (FHS) [10387]