Comparison of antigenicity of toxins produced by Clostridium botulinum type C and D strains.
dc.contributor.author | Ochanda, J.O. | |
dc.contributor.author | Syuto, B | |
dc.contributor.author | Oguma, K. | |
dc.contributor.author | Iida, H. | |
dc.contributor.author | Kubo, S. | |
dc.date.accessioned | 2013-07-11T13:33:27Z | |
dc.date.available | 2013-07-11T13:33:27Z | |
dc.date.issued | 1984 | |
dc.identifier.citation | O., PROFOCHANDAJAMES. 1984. Ochanda JO, Syuto B, Oguma K, Iida H, Kubo S.Comparison of antigenicity of toxins produced by Clostridium botulinum type C and D strains.Appl Environ Microbiol. 1984 Jun;47(6):1319-22. Appl Environ Microbiol. 1984 Jun;47(6):1319-22. : East African Medical Journal | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47497 | |
dc.description.abstract | C1 neurotoxin of Clostridium botulinum strains C-Stockholm (C-ST), C beta-Yoichi, C-468, CD6F, and C-CB19 and type D toxin of strains D-1873 and D-CB16 were purified by gel filtration, ion exchange, and affinity chromatographies. The purified toxins had di-chain structure made of heavy and light chains. The toxins of C beta-Yoichi, C-468, CD6F, and C-CB19 reacted with anti-C-ST heavy chain and anti-C-ST light chain in immunodiffusion tests and enzyme-linked immunosorbent assay, whereas D-CB16 toxin reacted with anti-D-1873 heavy chain and anti-D-1873 light chain. However, C-6813 toxin reacted with anti-D-1873 heavy chain and anti-C-ST light chain but not with anti-C-ST heavy chain or anti-D-1873 light chain immunoglobulin G. These results indicate common antigens in the heavy chains of C-6813 and D-1873 toxins and in the light chains of C-6813 and C-ST toxins. Further, they provide evidence for heterogeneity within type C1 toxin subunits. | |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Comparison of antigenicity of toxins produced by Clostridium botulinum type C and D strains. | en |
dc.type | Article | en |
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