Screening for HIV-associated peripheral neuropathy in resource-limited settings
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Date
2013Author
Cettomai, Deanna
Kwasa, Judith K
Birbeck, Gretchen L
Price, Richard W
Cohen, Craig R
Bukusi, Elizabeth A
Kendi, Caroline
Meyer, Ana-Claire L
Type
ArticleLanguage
enMetadata
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INTRODUCTION
Peripheral neuropathy is the most common neurological complication of HIV but is widely under-diagnosed in resource-limited settings. We investigated the utility of screening tools administered by non-physician health care workers (HCW) and quantitative sensory testing (QST) administered by trained individuals for identification of moderate/severe neuropathy.
METHODS
We enrolled 240 HIV-infected outpatients using two-stage cluster randomized sampling. HCWs administered the several screening tools. Trained study staff performed QST. Tools were validated against a clinical diagnosis of neuropathy.
RESULTS
Participants were 65% women, mean age 36.4 years, median CD4 324 cells/μL. 65% were taking antiretrovirals, and 18% had moderate/severe neuropathy. The screening tests were 76% sensitive in diagnosing moderate/severe neuropathy with negative predictive values of 84-92%. QST was less sensitive but more specific.
DISCUSSION
Screening tests administered by HCW have excellent negative predictive values and are promising tools for scale-up in resource-limited settings. QST shows promise for research use. © 2013 Wiley Periodicals, Inc.
URI
http://onlinelibrary.wiley.com/doi/10.1002/mus.23795/abstracthttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47580
Citation
Cettomai Deanna, Kwasa Judith K, Birbeck Gretchen L , Price Richard W, Cohen Craig R, Bukusi Elizabeth A, Kendi Caroline, Meyer Ana-Claire L;2013;Screening for HIV-associated peripheral neuropathy in resource-limited settings.Publisher
University of Nairobi, College of Health Science
Collections
- Faculty of Health Sciences (FHS) [10387]