dc.contributor.author | Cettomai, Deanna | |
dc.contributor.author | Kwasa, Judith K | |
dc.contributor.author | Birbeck, Gretchen L | |
dc.contributor.author | Price, Richard W | |
dc.contributor.author | Cohen, Craig R | |
dc.contributor.author | Bukusi, Elizabeth A | |
dc.contributor.author | Kendi, Caroline | |
dc.contributor.author | Meyer, Ana-Claire L | |
dc.date.accessioned | 2013-07-11T14:54:50Z | |
dc.date.available | 2013-07-11T14:54:50Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Cettomai Deanna, Kwasa Judith K, Birbeck Gretchen L , Price Richard W, Cohen Craig R, Bukusi Elizabeth A, Kendi Caroline, Meyer Ana-Claire L;2013;Screening for HIV-associated peripheral neuropathy in resource-limited settings. | en |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/mus.23795/abstract | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47580 | |
dc.description.abstract | INTRODUCTION
Peripheral neuropathy is the most common neurological complication of HIV but is widely under-diagnosed in resource-limited settings. We investigated the utility of screening tools administered by non-physician health care workers (HCW) and quantitative sensory testing (QST) administered by trained individuals for identification of moderate/severe neuropathy.
METHODS
We enrolled 240 HIV-infected outpatients using two-stage cluster randomized sampling. HCWs administered the several screening tools. Trained study staff performed QST. Tools were validated against a clinical diagnosis of neuropathy.
RESULTS
Participants were 65% women, mean age 36.4 years, median CD4 324 cells/μL. 65% were taking antiretrovirals, and 18% had moderate/severe neuropathy. The screening tests were 76% sensitive in diagnosing moderate/severe neuropathy with negative predictive values of 84-92%. QST was less sensitive but more specific.
DISCUSSION
Screening tests administered by HCW have excellent negative predictive values and are promising tools for scale-up in resource-limited settings. QST shows promise for research use. © 2013 Wiley Periodicals, Inc. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi, | en |
dc.subject | sensitivity and specificity;HIV;peripheral nervous system diseases;developing countries;screening tools | en |
dc.title | Screening for HIV-associated peripheral neuropathy in resource-limited settings | en |
dc.type | Article | en |
local.publisher | College of Health Science | en |