Cluster randomised trial of the uptake of a take-home infant dose of nevirapine in Kenya.
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Date
2010Author
Reynolds, HW
Gachuno, O
Kayita, J
Hays, MA
Otterness, C
Rakwar, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
To test whether a single take home dose of infant nevirapine increased infant uptake without decreasing institutional deliveries.
DESIGN:
Cluster randomised post-test only study with control group.
SETTING:
Ten hospitals in urban areas of Coast, Rift Valley, and Western provinces, Kenya.
PARTICIPANTS:
Pregnant women with HIV, 18 years and older, and at least 32 weeks gestation recruited during antenatal care and followed up at home approximately one week after delivery.
INTERVENTION:
In the intervention group, women were given a single infant's dose of nevirapine to take home prior to delivery. In the control group, no changes were made to the standard of care.
MAIN OUTCOME MEASURES:
Mothers' reports of infant uptake of nevirapine and place of delivery.
RESULTS:
Uptake of the infant's nevirapine dose was high, 94% in the intervention group and 88% in the control group (p=0.096). Among women who delivered at home, uptake was higher significantly among infants whose mothers got the take home dose compared to women who did not get the dose (93% vs. 53%, p<0.01). The intervention did not influence place of delivery. Providers were positive about the take home dose concept; difficulties were attributed to HIV-related stigma.
CONCLUSIONS:
Making take home infant nevirapine available, either as a single dose administered within 72 hours of birth or as part of a more complex six week postnatal regimen, will increase infant uptake especially among women who deliver at home without affecting place of delivery
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/23451547http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/48327
Citation
East Afr Med J. 2010 Jul;87(7):284-93.Publisher
MEASURE Evaluation, Carolina Population Center, Chapel Hill, NC, USA. Department of Obstetrics and Gynaecology, University of Nairobi, Kenya
Collections
- Faculty of Health Sciences (FHS) [10387]