Cross-clade CD8(+) T-cell responses with a preference for the predominant circulating clade.
View/ Open
Date
2005Author
McKinnon, LR
Ball, TB
Kimani, J
Wachihi, C
Matu, L
Luo, M
Embree, J
Fowke, KR
Plummer, FA.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Human immunodeficiency virus (HIV) genetic diversity is a major impediment to the design of a successful vaccine. Even if an HIV vaccine is proven effective, it remains to be seen whether this protection will extend to inter-clade, intra-clade, and recombinant strains. We used recombinant vaccinia-based interferon gamma (IFN) Elispot assays to test the inter-clade crossreactivity of clades A, B, C, and D HIV Env in two cohorts of HIV-infected Kenyans. Despite the tremendous diversity in this HIV protein, a substantial proportion of multi-clade responses were observed. Although these multi-clade responses correlated well with each other in regression analyses, clade A responses were seen at a higher frequency and at greater relative magnitudes in a proportion of these patients, when compared to the other three clades. Epitope mapping indicates CD8(+) T cell recognition of conserved regions of Env, accounting for the high degree of cross-reactivity but not the clade A preference. A better understanding of cross-clade CD8(+) T cell responses to HIV may help to predict whether a successful vaccine could be used to stop geographically and genetically distinct HIV epidemics.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/16249696http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/49372
Citation
J Acquir Immune Defic Syndr. 2005 Nov 1;40(3):245-9.Publisher
University of Nairobi Department of Medical Microbiology
Collections
- Faculty of Health Sciences (FHS) [10387]