dc.contributor.author | Naiki, M. | |
dc.contributor.author | Asano, T. | |
dc.contributor.author | Waiyaki, P.G., | |
dc.contributor.author | Noguchi, A., | |
dc.contributor.author | Mwangi, D.W., | |
dc.contributor.author | Mukuria, J.C | |
dc.date.accessioned | 2013-07-26T06:04:32Z | |
dc.date.available | 2013-07-26T06:04:32Z | |
dc.date.issued | 1995 | |
dc.identifier.citation | C, PROFMUKURIAJOSEPH. Mukuria, J.C 1995. ., . (1995). Evidence for a free N-acetylneuraminic acid . Biochemical Journal 305: 459 . : Plant Molecular Biology Reporter Vol. 27, pp. 79-85. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/51315 | |
dc.description.abstract | A preliminary short follow-up study of Hanganutziu and Deicher (HD) antibody titre and sialic acid levels in sera from 7 patients with hepatoma was carried out. Weekly HD antibody titres were abnormal in 6 patients with titres of 4 of the 6 falling to normal in some weeks. Sialic acids levels, however were abnormal (3.830-6.82mmol/ l) compared to those of 33 normal sera (1.08-2.73 mmol/1) throughout the 8 week screening period. There was a poor correlation between the antibody tires and the sialic acid levels (r<0.50) suggesting that at some stage of malignancy, the tumour was expressing N-glycolylneuraminic acid (Neu5Gc), the epitope of HD antigens as well as shedding into circulation, excess N-acetylneuraminic acid (Neu5Gc). Neu5Gc is a tumor-associated antigen. Measurement of antibodies to this epitope have shown that the antibodies have a potential of offering an alternative method of determining tumor growth and/or metastases. A major follow-up study incorporating information on cancer type, disease stage, therapy and the immnunological status of the patient is called for. | en |
dc.language.iso | en | en |
dc.title | Evidence for a free N-acetylneuraminic acid | en |
dc.type | Article | en |
local.publisher | Department of Biochemistry, University of Nairobi | en |