dc.contributor.author | Luscher, Mark A | |
dc.contributor.author | MacDonald, Kelly S | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Plummer, FA | |
dc.contributor.author | Barber, Brian H | |
dc.date.accessioned | 2013-07-26T08:26:42Z | |
dc.date.available | 2013-07-26T08:26:42Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Immunogenetics February 2001, Volume 53, Issue 1, pp 10-14 | en |
dc.identifier.issn | 0093-7711 | |
dc.identifier.issn | 1432-1211 | |
dc.identifier.uri | http://link.springer.com/article/10.1007/s002510100299 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/51521 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/11261925. | |
dc.description.abstract | As part of the ongoing study of natural HIV-1 resistance in the women of the Nairobi Sex Workers' study, we have examined a resistance-associated HLA class I allele at the molecular level. Typing by polymerase chain reaction using sequence-specific primers determined that this molecule is closely related to HLA-A*0214, one of a family of HLA-A2 supertype alleles which correlate with HIV-1 resistance in this population. Direct nucleotide sequencing shows that this molecule differs from A*0214, having a silent nucleotide substitution. We therefore propose to designate it HLA-A*02142. We have determined the peptide-binding motif of HLA-A*0214/02142 by peptide elution and bulk Edman degradative sequencing. The resulting motif, X-[Q,V]-X-X-X-K-X-X-[V,L], includes lysine as an anchor at position 6. The data complement available information on the peptide-binding characteristics of this molecule, and will be of use in identifying antigenic peptides from HIV-1 and other pathogens | en |
dc.language.iso | en | en |
dc.publisher | Springer-Verlag | en |
dc.title | Sequence and peptide-binding motif for a variant of HLA-A*0214 (A*02142) in an HIV-1-resistant individual from the Nairobi Sex Worker cohort | en |
dc.type | Article | en |
local.publisher | Department of Medicine, University of Toronto, Toronto, Canada, | en |
local.publisher | Department of Microbiology, Mount Sinai Hospital, Room 1484, 600 University Ave., Toronto, Ontario, M5G 1X5, Canada, | en |
local.publisher | Department of Microbiology, University of Nairobi, Nairobi, Kenya, | en |
local.publisher | Department of Medical Microbiology University of Manitoba, Winnipeg, Canada | en |
local.publisher | Department of Immunology, University of Toronto, Toronto, Canada, | en |