dc.contributor.author | Lule, GN | |
dc.contributor.author | Ogola, EN, | |
dc.contributor.author | Joshi, MD, | |
dc.contributor.author | Magada, A, | |
dc.date.accessioned | 2013-07-30T12:12:38Z | |
dc.date.available | 2013-07-30T12:12:38Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | DAVID, PROFJOSHIMARK. 2006. Homocysteine as a Risk Factor for Deep Venous Thrombosis At Kenyatta N Hospital,Nairobi. Magada A, Joshi MD, Ogola EN, Lule GN.. Healthline. 2006;10:48-51. : Institute of Health Research & Services | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52555 | |
dc.description.abstract | OBJECTIVE:To determine the aetiological role of Hyperhomocysteinemia in Deep Venous Thrombosis. STUDY DESIGN: Case Control Study STUDY SETTING: Tertiary National Referral Hospital; Kenyatta N Hospital. STUDY SUBJECTS: Cases: patients with a Compression Doppler Ultrasonography (CDU) index diagnosis of lower limb DVT; Controls: staff & out-patients with no clinical evidence or diagnostic suspicion of DVT. Main Outcome Measure: Odds ratio for Hyperhomocysteinemia Methods: Consecutive patients with a clinical suspicion of Index DVT underwent CDU by a single sonography, if positive were recruited with an equal number of matched controls.. Fasting plasma homocysteine levels were assayed, and level > 10umol/l was defined as Hyperhomocysteinemia (HH). Traditional DVT risk factors were evaluated and an Odds ratio for HH calculated. Results: Between September 2000 to March 2001 60 consecutive patients were screened and 57 recruited with 50 healthy hospital staff & 7 non DVT out patients as controls. Mean case age was 36.4 yrs 10.0 with of 18 to 63 yrs range. 94.7% were female and all native Africans. The most prevalent traditional risk factor was hormonal contraceptive use (33.4%); 14 patients (24.6%) had more than one risk factor. Mean case homocysteine levels was 13.2 4.9 mols/l and 11.1 3.49 mols/l. in controls. Odds Ratio for HH 1.58, (95% CI 0.068-3.65). Conclusions: DVT risk factors in our patient population is multifactorial and Hyperhomocysteinemia is associated with a 58% relative risk for DVT. | en |
dc.language.iso | en | en |
dc.title | Homocysteine as a Risk Factor for Deep Venous Thrombosis At Kenyatta N Hospital,Nairobi | en |
dc.type | Article | en |
local.publisher | Department of Clinical Medicine & Therapeutics, University of Nairobi | en |