Anti-Inflammatory and Anti-Diarrhoeal Activities of a Steroidal Indoxyl

dc.contributor.author	Kamau, FN
dc.contributor.author	Kibwage, IO
dc.contributor.author	Guantai, AN
dc.contributor.author	Muriuki, G
dc.contributor.author	Munenge, R
dc.date.accessioned	2013-07-31T09:10:09Z
dc.date.available	2013-07-31T09:10:09Z
dc.date.issued	2003
dc.identifier.citation	East and Central African Journal of Pharmaceutical Sciences Vol.6(2) 2003: 26-29	en
dc.identifier.uri	http://www.ajol.info/index.php/ecajps/article/view/9695
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52927
dc.description.abstract	The anti-inflammatory and antidiarrhoeal activities of 3β-Hydroxy-16, 17-seco-16-nor-5-androsten-15-(2-indoxyliden)-17-oic acid (I) are reported. After intraperitoneal administration, compound (I) gave an ED50 of 9.5 mg/kg using the carrageenan induced rat paw oedema anti-inflammatory assay method. Indomethacin had an ED50 of 5.8 mg/kg in this assay. Compound (I) and indomethacin caused comparable and dose-dependent varying degrees of delay in diarrhoea and also significantly reduced net colonic water flux into the colon of rats induced by castor oil. Key words: Steroidal Indoxyl, Anti-Inflammatory, Antidiarrhoeal.	en
dc.language.iso	en	en
dc.publisher	University of Nairobi	en
dc.subject	Steroidal Indoxyl, Anti-Inflammatory, Antidiarrhoeal.	en
dc.title	Anti-Inflammatory and Anti-Diarrhoeal Activities of a Steroidal Indoxyl	en
dc.type	Article	en
local.publisher	Department of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Nairobi.	en