Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity.
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Date
2008Author
Narender, T
Khaliq, T
Singh, AB
Joshi, MD
Mishra, P
Chaturvedi, JP
Srivastava, AK
Maurya, R
Agarwal, SC
Type
ArticleLanguage
enMetadata
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Ficus racemosa belongs to the family of Moraceae and is commonly known as 'Gular' in north India. Bio-activity guided isolation work on the fruits of F. racemosa resulted in the identification of antidiabetic active principle, alpha-amyrin acetate 7. Compound 7 lowered the blood glucose levels by 18.4 and 17.0% at 5 and 24 h, respectively, in sucrose challenged streptozotocin induced diabetic rat (STZ-S) model at the dose of 100 mg/kg body weight. Fifteen novel derivatives viz, 9-21, 24, 25 of alpha-amyrin 8 were prepared and their antihyperglycemic activity profile was assessed. The p-chlorobenzoic acid derivative 9 and nicotinic acid derivative 14 showed potent antihyperglycemic activity at 100 mg/kg body weight.
URI
http://www.ncbi.nlm.nih.gov/pubmed/18947904http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/53043
Citation
Eur J Med Chem. 2009 Mar;44(3):1215-22. doi: 10.1016/j.ejmech.2008.09.011. Epub 2008 Sep 19.Publisher
University of Nairobi Faculty of medicine
Collections
- Faculty of Health Sciences (FHS) [10387]