Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model.
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Date
2007Author
Singh, FV
Chaurasia, S
Joshi, MD
Srivastava, AK
Goel, A
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2-one and 6-(furan-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded streptozotocin-induced diabetic rat model. Five of the test compounds showed significant lowering of plasma glucose level in STZ-S model.
URI
http://www.ncbi.nlm.nih.gov/pubmed/17336063http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/53091
Citation
Bioorg Med Chem Lett. 2007 May 1;17(9):2425-9. Epub 2007 Feb 17.Publisher
University of Nairobi Faculty of medicine
Collections
- Faculty of Health Sciences (FHS) [10387]