Evidence for Efficient Vertical Transfer of Maternal HIV-1 Envelope-Specific Neutralizing Antibodies but No Association of Such Antibodies With Reduced Infant Infection
Date
2013-10-01Author
Omenda, MM
Milligan, C
Odem-Davis, K
Nduati, R
Richardson, BA
Lynch, J
John-Stewart, G
Overbaugh, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Little is known about the efficiency of vertical transfer of HIV-1-specific antibodies. Antibody levels in plasma from 60 mother-infant pairs near the time of birth, including 14 breast-feeding transmission pairs, were compared. The envelope-binding titers were strongly correlated (r = 0.91, P < 0.0001) and similar (1.4-fold greater in maternal plasma) between a mother and her corresponding infant as were the neutralizing antibody (Nab) levels (r = 0.80, P < 0.0001; 1.3-fold higher), suggesting efficient transfer. There was no significant difference in Nab responses between transmitting and nontransmitting mothers, although there was a trend for transmitting mothers to have higher HIV-1-specific Nabs.
Citation
J Acquir Immune Defic Syndr. 2013 Oct 1;64(2):163-166.Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]