Evidence for Efficient Vertical Transfer of Maternal HIV-1 Envelope-Specific Neutralizing Antibodies but No Association of Such Antibodies With Reduced Infant Infection
dc.contributor.author | Omenda, MM | |
dc.contributor.author | Milligan, C | |
dc.contributor.author | Odem-Davis, K | |
dc.contributor.author | Nduati, R | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Lynch, J | |
dc.contributor.author | John-Stewart, G | |
dc.contributor.author | Overbaugh, J | |
dc.date.accessioned | 2013-10-08T08:33:14Z | |
dc.date.available | 2013-10-08T08:33:14Z | |
dc.date.issued | 2013-10-01 | |
dc.identifier.citation | J Acquir Immune Defic Syndr. 2013 Oct 1;64(2):163-166. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57457 | |
dc.description.abstract | Little is known about the efficiency of vertical transfer of HIV-1-specific antibodies. Antibody levels in plasma from 60 mother-infant pairs near the time of birth, including 14 breast-feeding transmission pairs, were compared. The envelope-binding titers were strongly correlated (r = 0.91, P < 0.0001) and similar (1.4-fold greater in maternal plasma) between a mother and her corresponding infant as were the neutralizing antibody (Nab) levels (r = 0.80, P < 0.0001; 1.3-fold higher), suggesting efficient transfer. There was no significant difference in Nab responses between transmitting and nontransmitting mothers, although there was a trend for transmitting mothers to have higher HIV-1-specific Nabs. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Evidence for Efficient Vertical Transfer of Maternal HIV-1 Envelope-Specific Neutralizing Antibodies but No Association of Such Antibodies With Reduced Infant Infection | en |
dc.type | Article | en |
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