Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.
Date
2011Author
Cupit, PM
Steinauer, ML
Tonnessen, BW
Eric Agola, L
Kinuthia, JM
Mwangi, IN
Mutuku, MW
Mkoji, GM
Loker, ES
Cunningham, C
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya.
URI
http://www.ncbi.nlm.nih.gov/pubmed/21889508http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57594
Citation
Int J Parasitol. 2011 Oct;41(12):1249-52Publisher
Elsevier Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Collections
- Faculty of Health Sciences (FHS) [10387]