dc.contributor.author | Butler, SE | |
dc.contributor.author | Muok, EM | |
dc.contributor.author | Montgomery, SP | |
dc.contributor.author | Odhiambo, K | |
dc.contributor.author | Mwinzi, PM | |
dc.contributor.author | Secor, WE | |
dc.contributor.author | Karanja, DM | |
dc.date.accessioned | 2013-10-15T06:19:44Z | |
dc.date.available | 2013-10-15T06:19:44Z | |
dc.date.issued | 2012-11 | |
dc.identifier.citation | Butler SE,Muok EM,Montgomery SP, Odhiambo K,Mwinzi PM ,Secor WE, Karanja DM.Mechanism of anemia in schistosoma mansoni-infected school children in Western Kenya.Am J Trop Med Hyg.2012 Nov; 87 (5):874-82 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/22987658 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57615 | |
dc.description.abstract | A better understanding of the mechanism of anemia associated with Schistosoma mansoni infection might provide useful information on how treatment programs are implemented to minimize schistosomiasis-associated morbidity and maximize treatment impact. We used a cross-sectional study with serum samples from 206 Kenyan school children to determine the mechanisms in S. mansoni-associated anemia. Serum ferritin and soluble transferrin receptor levels were measured by using an enzyme-linked immunosorbent assay. Results suggest that S. mansoni-infected persons are more likely (odds ratio = 3.68, 95% confidence interval = 1.33-10.1) to have levels of serum ferritin (> 100 ng/mL) that are associated with anemia of inflammation (AI) than S. mansoni-uninfected children. Our results suggest that AI is the most common form of anemia in S. mansoni infections. In contrast, the mechanism of anemia in S. mansoni-uninfected children was iron deficiency. Moreover, the prevalence of AI in the study participants demonstrated a significant trend with S. mansoni infection intensity (P < 0.001). Our results are consistent with those observed in S. japonicum-associated anemia. | en |
dc.language.iso | en | en |
dc.title | Mechanism of anemia in schistosoma mansoni-infected school children in Western Kenya | en |
dc.type | Article | en |
local.publisher | School of Public Health | en |