Short report: Evaluation of hepatic fibrosis in persons co-infected with Schistosoma mansoni and human immunodeficiency virus 1. , ,, , , .
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Date
2004Author
Mwinzi, PN
Karanja, DM
Kareko, I
Magak, PW
Orago, AS
Colley, DG
Secor, WE
Type
ArticleLanguage
enMetadata
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Abstract
To investigate whether infection with human immunodeficiency virus 1 (HIV-1) affects fibrosis development in patients infected with Schistosoma mansoni, we evaluated schistosomiasis-induced pathology in the livers of Kenyan patients co-infected with HIV-1. Compared with persons with schistosomiasis alone (n = 58), there were no significant differences in distribution of ultrasound-detectable pathology in persons with HIV-1 co-infection (n = 23). Similarly, serum aspartate aminotransferase levels were not significantly different in HIV-1+ individuals. Hepatic fibrosis was associated with significantly decreased CD4+ T cell counts, even in the absence of HIV-1 infection. These data suggest that HIV-1 co-infection does not significantly alter the proportion of patients experiencing schistosomiasis-induced fibrosis, but pathology associated with S. mansoni infections leads to CD4+ T cell reductions and thereby may exacerbate the effects of HIV-1 in co-infected individuals
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57654http://www.ncbi.nlm.nih.gov/pubmed/15642972
Publisher
University of Nairobi College of Health Science
Description
Journal Article
Collections
- Faculty of Health Sciences (FHS) [10387]