dc.contributor.author | Karanja, DM | |
dc.contributor.author | Hightower, AW | |
dc.contributor.author | Colley, DG | |
dc.contributor.author | Mwinzi, PN | |
dc.contributor.author | Galil, K | |
dc.contributor.author | Andove, J | |
dc.contributor.author | Secor, WE | |
dc.date.accessioned | 2013-10-16T09:15:09Z | |
dc.date.available | 2013-10-16T09:15:09Z | |
dc.date.issued | 2002 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57659 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/12241930 | |
dc.description | Article | en |
dc.description.abstract | Abstract
BACKGROUND:
Previous studies have reported age-dependent development of resistance to reinfection by schistosomes and identified immunological correlates of this resistance. However, whether resistance exists that is independent of age effects has been questioned. We did a longitudinal investigation of reinfection by Schistosoma mansoni in an adult population with high occupational exposure.
METHODS:
We monitored a cohort of 96 male car washers working along the shores of Lake Victoria, Kenya during 349.7 person-years for frequency of water contact and infection with S mansoni. Patients were treated with praziquantel upon study entry and after reinfection with S mansoni. Bivariate analyses and a multivariate proportional hazards model were used to assess the effects of water contact, previous infections, and HIV-1 on S mansoni reinfection rates.
FINDINGS:
13 car washers did not get reinfected or only became reinfected after an extended time (91 weeks). 47 initially had a short time to reinfection (15 weeks) but on subsequent treatments showed increased time to reinfection (29-38 weeks). 36 consistently displayed short times to reinfection (<15 weeks) despite multiple reinfection and treatment cycles. Decreased CD4 T-cell counts in HIV-1-positive individuals corresponded to increased susceptibility to S mansoni reinfection.
INTERPRETATION:
Adults similarly exposed to schistosomiasis are either resistant to reinfection; susceptible, but develop resistance to reinfection after multiple treatments; or remain susceptible to reinfection. Thus, immunological resistance to reinfection with S mansoni exists or can develop independent of age effects. The consequence of HIV-1 co-infection suggests that CD4 T cells contribute to this resistance. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Resistance to reinfection with Schistosoma mansoni in occupationally exposed adults and effect of HIV-1 co-infection on susceptibility to schistosomiasis: a longitudinal study. | en |
dc.type | Article | en |
local.publisher | College of Health Science | en |