Cellular immune responses of schistosomiasis patients are altered by human immunodeficiency virus type 1 coinfection.
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Date
2001Author
Mwinzi, PN
Karanja, DM
Colley, DG
Orago, A S
Secor, WE
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
In vitro studies suggest that CD4(+) cells with a T helper 2 (Th2) phenotype better support human immunodeficiency virus type 1 (HIV-1) replication than do cells of the Th1 phenotype. As a result, Th2-type immune responses may be substantially affected by HIV-1 coinfection. To test this hypothesis, a comparison was done of proliferation and cytokine production by peripheral blood mononuclear cells from patients with schistosomiasis who were positive or negative for HIV-1. Patients with schistosomiasis with HIV-1 coinfections had significantly lower interleukin (IL)-4 and IL-10 production than did HIV-1-negative individuals. In contrast, interferon-gamma production levels were similar between the 2 groups. Furthermore, in patients with HIV-1, a decrease in CD4(+) T cells was correlated with an increased Th1:Th2 cytokine production ratio. The effect of praziquantel treatment on proliferation and cytokine responses also differed between HIV-1 infection groups. Thus, HIV-1 infection affects immune response patterns of patients with schistosomiasis
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57660http://www.ncbi.nlm.nih.gov/pubmed/11471107
Publisher
University of Nairobi College of Health Science
Description
Journal Article
Collections
- Faculty of Health Sciences (FHS) [10387]