The effect of treatment of schistosomiasis on blood plasma HIV-1 RNA concentration in coinfected individuals.
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Date
2000Author
Lawn, SD
Karanja, DM
Karanja, P
Andove, J
Colley, DG
Folks, TM
Secor, WE
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Abstract
OBJECTIVE:
To determine whether drug treatment of Schistosomiasis mansoni infection leads to a reduction in plasma HIV-1 RNA concentration in coinfected individuals.
METHODS:
Stool and plasma samples were obtained prospectively from a cohort of HIV-infected persons (n = 30) in Kisumu, Kenya, before and after treatment of schistosomiasis with praziquantel (mean follow-up, 5.6 months; range 1-15 months). Schistosomal circulating cathodic antigen (CCA) concentrations in plasma were determined by ELISA and fecal egg counts were determined by microscopy. HIV-1 RNA concentrations were measured in pre- and post-treatment plasma samples obtained from the patients whose stool samples remained free of schistosomal eggs for the great majority of the follow-up period.
RESULTS:
Comparison of pretreatment and follow-up samples revealed that mean +/- SD fecal egg burden was reduced by 96.7% (481.5+/-803.5 versus 16.1+/-24.4 eggs/g feces) and mean plasma CCA concentration decreased by 90.1% (3.22+/-3.26 versus 0.32+/-0.38 microg/ml). In contrast, mean plasma HIV-1 load increased from 3.60+/-0.90 to 3.93+/-0.95 log10 RNA copies/ml (P< 0.001). Although no correlation was found between changes in HIV-1 load and changes in schistosomal burden, there was a significant correlation between changes in plasma HIV load and the time interval between pretreatment and follow-up samples (r = 0.41; P = 0.027).
CONCLUSIONS:
Treatment of schistosomiasis was not associated with a reduction in plasma HIV-1 load. This study does not, however, exclude the possibility of an adverse effect of helminthic infections on HIV-1 pathogenesis.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57662http://www.ncbi.nlm.nih.gov/pubmed/11101053
Publisher
University of Nairobi College of Health Science
Collections
- Faculty of Health Sciences (FHS) [10387]