Antibody to chlamydial hsp60 predicts an increased risk for chlamydial pelvic inflammatory disease.
![Thumbnail](/bitstream/handle/11295/57700/Abstract.pdf.jpg?sequence=4&isAllowed=y)
View/ Open
Date
1997Author
Peeling, RW
Kimani, J
Plummer, F
Maclean, I
Cheang, M
Bwayo, J
Brunham, RC
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Abstract
To determine whether serum antibody to Chlamydia trachomatis antigens alters the risk of C. trachomatis pelvic inflammatory disease (PID), 280 female sex workers were prospectively evaluated over a 33-month period for incident C. trachomatis and Neisseria gonorrhoeae cervical infection and for clinical PID. At enrollment, women were tested for antibody to C. trachomatis elementary bodies by an indirect microimmunofluorescence assay and to recombinant chlamydial hsp60 (Chsp60) by an ELISA format. At each follow-up visit, women were tested for cervical chlamydial and gonococcal infection and were identified as having clinical PID if they complained of lower abdominal pain and were found to have uterine and adnexal tenderness on pelvic examination. The data demonstrate that antibody to Chsp60 predicts a 2- to 3-fold increased risk for C. trachomatis PID.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57700http://www.ncbi.nlm.nih.gov/pubmed/9129079
Publisher
University of Nairobi College of Health Science
Collections
- Faculty of Health Sciences (FHS) [10387]