In vitro activity of azithromycin in Salmonella isolates from Pakistan.
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Date
2011-05Author
Butt, F
Sultan, F.
Type
ArticleLanguage
enMetadata
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INTRODUCTION:
Enteric fever is caused by Salmonella enterica serovars Typhi and Paratyphi A, B and C. It is a significant public health issue in Pakistan, which is exacerbated by a high level of resistance some isolates display to drugs routinely used in treatment. Azithromycin may be a treatment option for such isolates.
METHODOLOGY:
We determined the minimum inhibitory concentrations (MICs) of Salmonella Typhi and Paratyphi isolates against azithromycin in an attempt to gauge its feasibility as a therapeutic option. The MICs were also compared with corresponding disc diffusion zone sizes to see if there was consistency between the two tests. We tested 45 Salmonella enterica isolates using E-tests for MIC detection and azithromycin discs with a concentration of 15µg/ml for disc diffusion testing.
RESULTS:
Salmonella Typhi, Salmonella Paratyphi A, and Salmonella Paratyphi C isolates demonstrated MICs of 2-12mg/L against azithromycin, suggesting that the antibiotic could be used for therapeutic purposes. For Salmonella Paratyphi B, the MICs were 2-48 mg/L. The higher MIC indicates a need for caution when considering use of azithromycin for Salmonella Paratyphi B infections without first testing for the MIC. There was a close correlation between MICs and zone sizes which was statistically significant.
CONCLUSIONS:
Our results indicate azithromycin is a potential therapeutic option for enteric fever. Standardized laboratory testing methods and interpretation for azithromycin against Salmonella enterica would allow laboratories to report upon this antibiotic with confidence
URI
http://www.ncbi.nlm.nih.gov/pubmed/21628817http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/58219
Citation
J Infect Dev Ctries. 2011 May 28;5(5):391-5.Publisher
University of Nairobi school of public health
Collections
- Faculty of Health Sciences (FHS) [10387]