dc.contributor.author | Mugo, Peter N | |
dc.date.accessioned | 2013-11-20T06:26:43Z | |
dc.date.available | 2013-11-20T06:26:43Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | A thesis submitted in partial fulfillment of the requirements for the degree of Master of Medicine in Internal Medicine of the University of Nairobi | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/59520 | |
dc.description.abstract | Background: Pulmonary impairment following TB treatment has been described in selected
populations. No previous studies have evaluated the effects of treated pulmonary TB on lung
function and QOL in Kenya.
Methods: This was a cross sectional study conducted at Riruta, Kangemi and Kibera Health
Centres between May and June 2012. Patients with cured smear positive TB in the last 2 years
were assessed for their current health status using the St Georges Respiratory questionnaire
and pulmonary function using spirometry.
Results: Of 409 eligible patients, 183 (58% males) were enrolled. There were no significant
differences in the demographic profiles of the study subjects and non responders.
53 patients (29%) had pulmonary impairment, the commonest being restrictive defects in 42
patients (23%, 95% CI 16.8-29.1%), obstructive defects in 9 patients (5%, 95% CI 1.76-8.08%)
and combined defects in 2 patients (1%, 95% CI -0.4-2.61%). Patients with abnormal lung
function were younger {median age, 29 years (IQR, 22-36) vs 34 years (IQR, 27-39), p= 0.036},
more likely to be underweight (38% vs 9%, P= <0.005) and had a lower prevalence of HIV
(20.8% vs 37.7%, p=0.027). Low BMI was the only independent predictor of pulmonary function
abnormality (p=0.001). The median QOL total score from the SGRQ was 3.16 (IQR, 0 – 8.9)
signifying good QOL. There was no correlation between QOL and pulmonary function.
Conclusions: The commonest lung function abnormality post TB treatment was restrictive
defect. The QOL in this population was good. Body mass index was the only independent
predictor of abnormal pulmonary function. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Pulmonary function and quality of life in patients with treated smear positive pulmonary tuberculosis at Riruta, Kangemi and Kibera tuberculosis Clinics in Nairobi | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | School of Medicine | en |