Dilated cardiomyopathy and myocarditis in Kenya: an endomyocardial biopsy study.
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Date
1993-09Author
Sanderson, JE
Olsen, EG
Gatei, David
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
We have studied, by light and electron microscopy, left ventricular endomyocardial biopsy specimens from 18 African patients (14 men) with idiopathic dilated cardiomyopathy in Nairobi. Nine patients (50%) had evidence of healing myocarditis, that is the presence of a mild inflammatory cell infiltration within the myocardium. Interstitial fibrosis was prominent in five patients (28%) and in all 18 specimens there were hypertrophied muscle fibres. Therefore, half of the patients with idiopathic dilated cardiomyopathy had histological signs of a previous myocarditis. There was no serological evidence of a previous or recent coxsackie infection or any other common viral infections. It seems probable that the myocarditis was due to an inappropriate immunological reaction to myocardial muscle.
URI
http://www.ncbi.nlm.nih.gov/pubmed/8282440http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/60850
Citation
Int J Cardiol. 1993 Sep;41(2):157-63.Publisher
University of Nairobi School of Medicine
Collections
- Faculty of Health Sciences (FHS) [10387]