Individual and partner risk factors associated with abnormal cervical cytology among women in HIV-discordant relationships.
![Thumbnail](/bitstream/handle/11295/61678/ABSTRACT.pdf.jpg?sequence=4&isAllowed=y)
View/ Open
Date
2013Author
Soh, J
Rositch, AF
Koutsky, L
Guthrie, BL
Choi, RY
Bosire, RK
Gatuguta, A
Smith, JS
Kiarie, J
Lohman-Payne, B
Farquhar, C.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Individual and sexual partner characteristics may increase the risk of abnormal cervical cytology among women in human immunodeficiency virus (HIV)-discordant relationships. Papanicolaou smears were obtained in a prospective cohort of Kenyan HIV-discordant couples. Of 441 women, 283 (64%) were HIV-infected and 158 (36%) were HIV-uninfected with HIV-infected partners. Overall, 79 (18%) had low-grade and 25 (6%) high-grade cervical abnormalities. Male herpes simplex virus type 2 (HSV-2) seropositivity and lower couple socioeconomic status were associated with cervical abnormalities (p < 0.05). HIV-uninfected women with HIV-infected male sex partners (CD4 > 350 cells/µL) had the lowest prevalence of high-grade cervical lesions. HIV-infected women (CD4 > 350 cells/µL) and HIV-uninfected women with HIV-infected partners (CD4 ≤ 350 cells/µL) were at similar intermediate risk (p > 0.05), and HIV-infected women (CD4 ≤ 350 cells/µL) had significantly higher risk of high-grade cervical abnormalities (p = 0.05). Women in HIV-discordant relationships have high rates of cervical lesions and this may be influenced by couple-level factors, including HIV status and CD4 count of the infected partner.
Citation
Int J STD AIDS. 2013 Oct 7. [Epub ahead of print]Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]