In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects.
Date
2003Author
Muregi, FW
Chhabra, SC
Njagi, EN
Lang'at-Thoruwa, CC
Njue, WM
Orago, AS
Omar, SA
Ndiege, IO
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC(50) < 100 microg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC(50) values ranging less than 30 microg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC(50) values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ.
Citation
J Ethnopharmacol. 2003 Feb;84(2-3):235-9.Publisher
Elsevier
Collections
- Faculty of Health Sciences (FHS) [10387]