dc.description.abstract | BACKGROUND: The pattern of congenital oral and craniofacial anomalies
(CFAs)in the Kenyan population remains unknown. The few studies on wholebody
congenital anomalies in Kenya and other African countries have
suggestedthat the pattern of anomalies may be significantly different from
thosereported in other races worldwide. Kenyan studies have reported on
anencephaly, hydrocephalus, encephalocoeles and cleft lip and palate with
no mention of the other oral and craniofacial anomalies such as astomia,
aglossia, microtia, or preauricular sinuses and tags. Therefore, the pattern of
occurrence of these anomalies needed to be established.
OBJECTIVE: To describe the pattern of occurrence of CFAs at two hospitals in
thecity of Nairobi.
DESIGN: A descriptive cross-sectional study.
SETTING: Kenyatta National Hospital (KNH) and Pumwani Maternity Hospital
(PMH).
SUBJECTS AND METHOD: The study was done from November 2006 to March
2007. All mothers who delivered at the two hospitals were consented for
interview and examination of their babies. All births were physically
examined within 48 hours by the investigators for any anomalies from head to
toe and intra-orally using a clinical examination form. Anomalous infants
were classified for type, location and magnitude of anomalies. Data were
analysed to determine the association of these anomalies with ages of
mothers,gender, weight, birth order, mode of delivery and birth stotus of the
babiesusing the statistical package for social science (SPSS) software version
12.0 and Epilnfo package. Descriptive and inferential statistics were done
usingthe X2 and Fisher exact tests.
RESULTS: During the study period 7989 babies were born in the two hospitals
among whom 4264 (53.5%) were males and 3721(46.6%) were females and
4(0.1%) had ambiguous external genitalia. Total whole body anomalies were
256 (3.2%) among all births. Anomalous males were 142 (1.8%) and females
XII
were110(1.4%) of all the neonates. The most common single anomaly was
preauricular sinus constituting 34(4.3/1000) of the total births, followed by
extradigits at 22(2.8/1000), then talipes at 20(2.5/1000) of total births. Total
CFAswere 146, comprising 57.3% of whole body anomalies and 1.8% of the
total livebirths. CFAs were more common in female livebirths (1.4%) than the
male (1.0%)livebirths. However, a total of 23.3% of stillbirths had CFAs, with
lesionsmanifesting more commonly in the males (16.5%) than the females
(6.8%).The commonest CFA was preauricular sinus 0.4% (4.3/1000births)
followedby hydrocephalus at 0.19% (1.9/1000) then cleft lip and palate and
preauricular tags at a prevalence of 1.6/1000 and 1.5/1000 respectively.
Anomalieswere significantly common in the first birth order and tapered off
steeplypast the fifth born. Out of a total of 5930 spontaneous vertex deliveries
(SVDs)148 (2.5%) had anomalies and out of 2059 caesarean sections CCSs)
103(5.0%) had anomalies. Major CFAs occurred at 0.6% (6.1/1000) in the
livebirthsand at 65.3% of the stillbirths while single minor anomalies occurred
at a rate of 1.1% (11.3/1000) of the total births. Multiple major anomalies were
common in stillbirths (85.7%).
CONCLUSION: The commonest CFAs were preauricular sinus, hydrocephalus
andclefts of the lip and palate. The anomalies were significantly common in
thefirst and second birth-order, low birth weight babies, in babies delivered
via caesarean section and in male stillbirths, comparing well with the findings
by other investigators in the literature. Minor CFAs were significantly
associated with other clinically recognizable anomalies all over the body.
Major CFAs were fatal in more than half the time within 48 hours perinatally. | en_US |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |