Neurotrophic And Antileukemic Daphnane Diterpenoids From Synaptolepis Kirkii
Date
2002-10Author
He, Weidong
Cik, Miroslav
Van Puyvelde, Luc
Van Dun, Jacky
Appendino, Giovanni
Lesage, Anne
Van der Lindin, Ilse
Leysen, Josée E
Wouters, Walter
Mathenge, Simon G
Mudida, Francis P
De Kimp, Norbert
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.
A bioassay-guided fractionation led to the isolation of kirkinine (6), kirkinine B (7), C (8), D (3), E (9), synaptolepis factor K7 (1), excoecariatoxin (2), yuanhuadine (4) and 12β-acetoxyhuratoxin (5) from the root of Synaptolepis kirkii, which possess potential neurotrophic and antileukaemia activities.
URI
http://www.sciencedirect.com/science/article/pii/S0968089602001633http://hdl.handle.net/11295/65716
Citation
Bioorganic & Medicinal Chemistry Volume 10, Issue 10, October 2002, Pages 3245–3255Publisher
University of Nairobi