dc.contributor.author | Chasela, CS | |
dc.contributor.author | Kourtis, AP | |
dc.contributor.author | Wall, P | |
dc.contributor.author | Drobeniuc, J | |
dc.contributor.author | King, CC | |
dc.contributor.author | Thai, H | |
dc.contributor.author | Teshale, EH | |
dc.contributor.author | Hosseinipour, M | |
dc.contributor.author | Ellington, S | |
dc.contributor.author | Codd, MB | |
dc.contributor.author | Jamieson, DJ | |
dc.contributor.author | Knight, R | |
dc.contributor.author | Fitzpatrick, P | |
dc.contributor.author | Kamili, S | |
dc.contributor.author | Hoffman, I | |
dc.contributor.author | Kayira, D | |
dc.contributor.author | Mumba, N | |
dc.contributor.author | Kamwendo, DD | |
dc.contributor.author | Martinson, F | |
dc.contributor.author | Powderly, W | |
dc.contributor.author | Teo, CG | |
dc.contributor.author | van der Horst, C | |
dc.contributor.author | BAN Study Team. | |
dc.contributor.author | Meme, J | |
dc.date.accessioned | 2014-04-29T15:15:54Z | |
dc.date.available | 2014-04-29T15:15:54Z | |
dc.date.issued | 2014-03 | |
dc.identifier.citation | J Hepatol. 2014 Mar;60(3):508-14. doi: 10.1016/j.jhep.2013.10.029. Epub 2013 Nov 6. | en_US |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/24211737 | |
dc.identifier.uri | http://hdl.handle.net/11295/66157 | |
dc.description.abstract | BACKGROUND & AIMS:
The extent of HBV infection to infants of HBV/HIV-coinfected pregnant women in sub-Saharan Africa is unknown. The aim of this study was to assess prevalence of HBV infection among antiretroviral-naïve, HIV-infected pregnant women in Malawi and examine HBV transmission to their infants.
METHODS:
Plasma from 2048 HIV-infected, Malawian women and their infants were tested for markers of HBV infection. Study participants were provided standard-of-care health services, which included administration of pentavalent vaccine to infants at 6, 10, and 14 weeks of age.
RESULTS:
One-hundred and three women (5%) were HBsAg-positive; 70 of these HBsAg-positive women were also HBV-DNA-positive. Sixteen women (0.8%) were HBV-DNA-positive but HBsAg-negative. Five of 51 infants (9.8%) born to HBsAg-positive and/or HBV-DNA-positive women were HBV-DNA-positive by 48 weeks of age.HBV DNA concentrations of two infants of mothers who received extended lamivudine-containing anti-HIV prophylaxis were <4 log10 IU/ml compared to ⩾ 8 log10 IU/ml in three infants of mothers who did not.
CONCLUSIONS:
HBV DNA was detected in nearly 10% of infants born to HBV/HIV-coinfected women. Antenatal testing for HIV and HBV, if instituted, can facilitate implementation of prophylactic measures against infant infection by both viruses. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.subject | Antiviral therapy | en_US |
dc.subject | HIV | en_US |
dc.subject | Hepatitis | en_US |
dc.subject | Mother-to-child transmission | en_US |
dc.subject | Sub-Saharan Africa | en_US |
dc.title | Hepatitis B virus infection among HIV-infected pregnant women in Malawi and transmission to infants. | en_US |
dc.type | Article | en_US |