Sexually Transmitted Diseases and Human Immunodeficiency Virus Control in Malawi: A Field Study of Genital Ulcer Disease
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Date
1995Author
Behets, Frieda M-T
Liomba, George
Lule, Godfrey
Dallabetta, Gina
Hoffman, Irving F
Hamilton, Holli A
Moeng, Stoffel
Cohen, Myron S
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Men with genital ulcer disease (GUD) attending a clinic in Malawi were evaluated and treated with one of five drug regimens. Haemophilus ducreyi was isolated from 204 (26.2%) of 778 patients. Of 677 men, 198 (29.2%) had treponemes detected in ulcer material by direct immunofluorescence or had rapid plasma reagin reactivity of ⩽5?1:8. Human immunodeficiency virus type 1 (HIV-l) seroprevalence was 58.9% overall and 75.8% among patients reporting a history of GUD (P < .001). By logistic regression analysis, HIV-l seropositivity was shown to impair ulcer healing (P = .003). Treatment failure rates for culture-proven chancroid were 19% for trimethoprim-ulfamethoxazole, 12.9% and 7.4%, respectively, for low- and high-dose erythromycin regimens, and 8.3% and 0, respectively, for low- and high-dose ciprofloxacin regimens. Herpes
antigen was detected by EIA in 6 (23.1%) of 26 nonhealing ulcers. In Malawi, GUD should be managed as a syndrome to assure treatment of both syphilis and chancroid.
Citation
Behets, F. M. T., Liomba, G., Lule, G., Dallabetta, G., Hoffman, I. F., Hamilton, H. A., ... & Cohen, M. S. (1995). Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease. Journal of Infectious Diseases, 171(2), 451-455.Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]