A Prospective Cohort Study of the Effect of Depot Medroxyprogesterone Acetate on Detection of Plasma and Cervical HIV-1 in Women Initiating and Continuing Antiretroviral Therapy
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Date
2014-05Author
Day, S
Graham, SM
Masese, LN
Richardson, BA
Kiarie, JN
Jaoko, W
Mandaliya, K
chohan, V
Overbaugh, J
McClelland, Scott R.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Depot medroxyprogesterone acetate (DMPA) use among HIV-1 infected women may increase transmission by increasing plasma and genital HIV-1 RNA shedding. We investigated associations between DMPA use and HIV-1 RNA in plasma and cervical secretions. 102 women initiated ART, contributing 925 follow-up visits over a median of 34 months. Compared to visits with no hormonal contraception exposure, DMPA exposure did not increase detection of plasma (adjusted odds ratio (AOR) 0.81, 95% CI 0.47-1.39) or cervical HIV-1 RNA (AOR 1.41, 95% CI 0.54-3.67). Our results suggest that DMPA is unlikely to increase infectivity in HIV-positive women who are adherent to effective ART.
Citation
J Acquir Immune Defic Syndr. 2014 May 4. [Epub ahead of print]Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]