Histopathology Of Various Organs In Patients With Acquired Immunodeficiency Syndrome {AIDS}.
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Date
1990-05Author
Mwangi, Christina
Type
ThesisLanguage
enMetadata
Show full item recordAbstract
The significance of histological patterns with accompanying
laboratory data seen in thirty patients with acquired
immunodeficiency syndrome at Kenyatta National Hospital are
described in relation to symptom and sign complexes. Ten of
these are postmortem and twenty antemortem.
There is a preponderance of Kaposi's sarcoma slit forming
type occurring in 70% of all the cases. Forty percent of
them present with skin nodules, 13% with lymphadenopathy,
13% with visceral involvement only, 3.3% with both visceral
and cutaneous lesions and 3.3% with a conjunctivas lesion.
Forty percent of the lymph nodes show granulomatous
lymphadenitis with necrosis, 40% Kaposi's sarcoma and 20%
follicular hyperplasia. Lymphoid depletion, follicular
changes and linear hyalinisation is noted in autopsy. The
spleen shows paucity of follicles in all the autopsy cases.
Approximately twenty seven percent (26.7%) of the study
patients are diagnosed as pulmonary tuberculosis antemortem.
At autopsy 40% of the cases have non-specific
broncho-pneumonia, 40% necrotising bz-onchopneumon ia. 10%
interstitial pneumonia infections or malignancies.
Diarrhoea occur in 36.7% of the cases is predominantly
non-infective in nature.
Myocardiolysis, focal segmental proliferative
glomerulonephritis and
cases. Testicular at (5 cases) and paucity of
epatolysis are seen in all the
primordial follicles ses are described.
Prospects for improved management
Kenyatta National Hospital and
of patients with AIDS at
future research are
suggested.
Citation
Degree of Master of Medicine (Pathology),Publisher
University of Nairobi