Serum Vitamin D Profile In Black African Men with Prostate Cancer at Tertiary Referral Facility in Sub-Saharan Africa
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Date
2014Author
Odhiambo, AO
Kiarie, GW
Ngugi, MP.
Joshi, MD
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Background:
Considerable epidemiological, in vitro, in vivo and clinical data support an association between
vitamin D deficiency and prostate cancer
risk and
outcome.
Few studies have examined
t
his association
in
African men with p
rostate cancer.
The vitamin D status in pat
ients with prostate cancer in Kenya is unknown.
This study aimed to determine the profile of vitamin D levels in patients with prostate cancer and to correlate
this
to
patient and disease characteristics.
Methods:
H
ospital
-
based cross
-
sectional
study
that evaluated
black
African men with incident or 3
-
month
prevalent
histologically confirmed prostate cance
r
seeking
ambulatory care at KNH
.
M
edical
history was
obtained by direct interview and the information recorded in questionnaires.
Treatment history
, pre
-
diagnostic
serum PSA and Gleason score were abstracted from patient records.
Every participant had their
anthropometric measurements taken and plasma samples drawn for 25
-
hydroxyvitamin D (25
-
VD)
concentrations
using the LIAISON® 25
-
OH automated chem
iluminescent immunoassay method
. The
relationship between age, body mass index, pre
-
diagnostic
serum
PSA and Gleason score on vitamin D status
was evaluated using
bivariate
and multivariate analysis.
Results:
162
black
African men were evaluated. The mean 25
-
VD was 19.15 ng/ml and 144 (88.
9
%) men
had
vitamin
D deficiency (25
-
VD < 30ng/ml).
29 (17.9%) were severely deficient (25
-
VD < 10ng/ml), 115 (71%)
were moderately deficie
nt (10
-
<
30 ng
/ml) and 18 (11.1%) were normal (
30
-
100ng/ml). Gleason scores
>
7 (OR
2.9
; 95% CI
1.5
-
5.5
,
p = 0.001) and serum PSA
≥
50ng/ml (OR 2.2
; 95% CI
1.7
-
5.1
,
p = 0.014) were associated
with vitamin D deficiency (25
-
VD < 20ng/ml) whereas age and BMI were not.
Adjusted for age, BMI and serum
PSA l
evels, having Gleason scores
>
7 was
independently associated with vitamin D deficiency (OR 2.5
; 95%
CI
1.2
–
4.9
,
p = 0.01).
Conclusion:
Vitamin D deficiency is
very
common in
black
African men with prostate cancer,
p
articularly in
those with
higher
Gleason scores.
URI
https://profiles.uonbi.ac.ke/andrew_/files/vitamin_d_prostate_cancer_iosr_jdms.pdfhttp://hdl.handle.net/11295/71749
Citation
Odhiambo, A. O., Kiarie, G. W., Ngugi, M. P., & Joshi, M. D. Serum Vitamin D Profile In Black African Men with Prostate Cancer at Tertiary Referral Facility in Sub-Saharan Africa.-Volume 13,Issue 4, Ver. III. (Apr. 2014), PP 60-64Publisher
University of Nairobi,
Collections
- Faculty of Health Sciences (FHS) [10386]