Combination adjuvants: The next generation of adjuvants?
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Date
2012Author
George, Mutwiri
Sylvia, van Drunen
Littel-van, den Hurk
Volker, Gerdts
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Adjuvants are critical components of many vaccines. The majority of existing vaccines contain only
a single adjuvant. Due to their inherent limitations, no single adjuvant is capable of inducing all the
protective immune responses required in the many different vaccines. Consequently, investigators are
exploring the potential of using multiple adjuvants (“cocktails”) in a vaccine. An emerging paradigm
is that careful selection of adjuvant combinations can result in complimentary and even synergistic
enhancement of immune responses to vaccines. This approach is promising and presents tremendous
opportunities for vaccinologists to tailor immune responses for specific vaccines. Combination
adjuvants at different stages of development and their potential in veterinary medicine will be
discussed.