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Antiparasitic And Antimicrobial Constituents From Terminalia Brownii

dc.contributor.authorMachumi, F
dc.contributor.authorZhang, J
dc.contributor.authorMidiwo, JO
dc.contributor.authorJacob, MR
dc.contributor.authorKhan, SI
dc.contributor.authorTekwani, BL
dc.contributor.authorWalker, LA
dc.contributor.authorMuhammad, I
dc.date.accessioned2014-08-14T12:14:51Z
dc.date.available2014-08-14T12:14:51Z
dc.date.issued2013
dc.identifier.citationMachumi, F., Zhang, J., Midiwo, J. O., Jacob, M. R., Khan, S. I., Tekwani, B. L., ... & Muhammad, I. (2013). Antiparasitic and Antimicrobial Constituents from Terminalia brownii. Planta Medica, 79(10), PN22.en_US
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0033-1348703
dc.identifier.urihttp://hdl.handle.net/11295/73764
dc.description.abstractTerminalia brownii is an African medicinal plant used to treat parasitic and microbial infections. A new oleanane-type triterenoid was isolated from its stem bark extract by bioassay-guided fractionation using the method of chromatographic separations and was identified as 3,24-O-ethylidenyl-2,19-dihydroxyolean-12-en-28-oic acid (1), along with seven known oleanane-type triterpenoids and seven ellagic acid derivatives. The compounds were evaluated for their antiplasmodial, antileishmanial and antimicrobial activities giving the most potent antiplasmodial activity with IC50 values of 2.76 µg/mL for 23-galloylarjunolic acid (2) against P. falciparum W2 strain and the most potent antimicrobial activity with IC50 values of 0.32 µg/mL for diellagic lactone (3) against C. glabrata.en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.titleAntiparasitic And Antimicrobial Constituents From Terminalia Browniien_US
dc.typeArticleen_US
dc.type.materialenen_US


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