HIV-1 Subtype D Infection Is Associated with Faster Disease Progression than Subtype A in Spite of Similar Plasma HIV-1 Loads
Date
2007Author
Baeten, Jared M
Chohan, Bhavna
Lavreys, Ludo
Chohan, Vrasha
McClelland, R Scott
Certain, Laura
Mandaliya, Kishorchandra
Jaoko, Walter
Julie, Overbaugh
Language
enMetadata
Show full item recordAbstract
We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality (hazard ratio, 2.3 [95% confidence interval, 1.0–5.6]) and a faster rate of CD4 cell count decline (P = .003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.
Citation
J Infect Dis. (2007) 195 (8): 1177-1180.Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10385]